All About Canine Epilepsy: A Heartbreaking Condition

Belgian tervueren are listed among the breeds for which a genetic factor for canine epilepsy is either proved or highly suspected.

It happened without warning. One moment my young male Belgian tervueren was snuggling against me as I sat on the couch; the next moment he lost control of his hindquarters and fell onto his side, unconscious.

His lips writhed back over his teeth; his legs stretched out, then became rigid; and his head twisted up and back as if an unseen hand was trying to raise his chin to an impossible height.

It seemed like an eternity, but actually only 2 minutes passed before his body relaxed and consciousness slowly ebbed back. For an hour afterward he seemed exhausted and disoriented.

I was shaken too, never having witnessed such a seizure before. Yet later that day the dog was romping about as if nothing out of the ordinary had occurred.

My dog is lucky. His seizures have been few and far between. We now believe they are caused by hypothyroidism. Other dogs are not so lucky. Seizures can be severe and frequent. They may occur in “clusters” (several in one day), or progress to the life-threatening state of status epilepticus. In extreme cases where seizures cannot be controlled, a veterinarian may advise euthanasia.

Epilepsy is found in all breeds and mixed breeds of dogs. Belgian tervueren are listed among the breeds for which a genetic factor is either proved or highly suspected. Other breeds so listed include:

  • Beagles
  • Dachshunds
  • German Shepherd dogs
  • Keeshonds

A high incidence of seizure disorders is also found in:

  • Boxers
  • Cocker spaniels
  • Collies
  • Golden retrievers
  • Irish setters
  • Labrador retrievers
  • Miniature schnauzers
  • Poodles
  • Saint Bernards
  • Siberian huskies
  • Wire-haired terriers

The prevalence of epilepsy in the general dog population has been estimated at 0.5 to 5.7 percent.

The term “epilepsy” can be confusing because some people use it to describe recurrent seizures of any cause, while others use it to specify recurrent seizures unrelated to brain disorders or underlying disease processes. The definitions below are helpful in distinguishing types of epilepsy.

Types of Canine Epilepsy

Primary epilepsy

Also known as idiopathic, genetic, inherited, or true epilepsy. There are no positive diagnostic findings that will substantiate the diagnosis. It is a case of ruling out every other possibility.

The first seizure in a dog with primary epilepsy usually occurs between 6 months and 5 years old. However, a diagnosis of primary epilepsy is not proof of a genetic defect — only careful breeding studies could prove that.

The breed, the age, and the history may suggest a genetic basis for primary epilepsy if there is a familial history of seizures.

Secondary epilepsy

This refers to seizures for which a cause can be determined, and there are many.

In dogs less than 1 year of age, the most commonly found causes of seizures can be broken down into the following classes:

  • Degenerative (storage diseases)
  • Developmental (hydrocephalus)
  • Toxic (lead, arsenic, organophosphates, chlorinated hydrocarbons, strychnine, tetanus)
  • Infectious (distemper, encephalitis, and others)
  • Metabolic (such as transient hypoglycemia, enzyme deficiency, liver or kidney failure)
  • Nutritional (thiamine, parasitism)
  • Traumatic (acute injury)

In dogs 1–3 years old, a genetic factor is most highly suspected. In dogs 4 years of age and older, seizures are commonly found in the metabolic (hypoglycemia, cardiovascular arrhythmia, hypocalcemia, cirrhosis) and neoplastic (brain tumor) classes.

Abnormal behaviors may last minutes or hours and can be followed by a generalized seizure.

Types of Seizures in a Dog

The types of seizures most commonly reported are listed below. If you believe your dog is having a seizure, it is important to note all the details so that you may accurately describe it to your veterinarian.

Types of seizures include:

Generalized seizure

Tonic-clonic (may be grand mal or mild): In the grand mal seizure, the tonic phase occurs as the animal falls, loses consciousness, and extends its limbs rigidly. Respiration also stops (apnea).

This phase usually lasts 10–30 seconds before the clonic phase begins. Clonic movements include paddling of the limbs and/or chewing. Other signs that appear during the tonic or clonic phase are dilation of the pupils, salivation, urination, and defecation.

The mild seizure involves little or no paddling or extension of limbs, and usually no loss of consciousness. Generalized seizures are usually associated with primary epilepsy.

Petit mal seizure (aka absence seizure)

Depending on the authority quoted, petit mals are described as either very rare or usually unrecognized in animals. Signs are brief (seconds) duration of unconsciousness, loss of muscle tone, blank stare, and possibly upward rotation of eyes.

The term petit mal should only be accorded to cases manifesting specific clinical signs and EEG abnormalities.

Partial seizures

Movements are restricted to one area of the body, such as muscle jerking, movement of one limb, turning the head or bending the trunk to one side, or facial twitches.

A partial seizure can progress to (and be mistaken for) a generalized tonic-clonic seizure, but the difference can be established by noting whether or not a seizure starts with one specific area of the body. Partial seizures are usually associated with secondary epilepsy.

Complex partial seizures (aka psychomotor or behavioral) seizures

These are associated with bizarre or complex behaviors that are repeated during each seizure.

People with complex partial seizures experience distortions of thought, perception or emotion (usually fear), sometimes with unusual visual, olfactory, auditory and gustatory sensations. If dogs experience the same things, it may explain the lip-smacking, chewing, fly biting, aggression, vocalization, hysterical running, cowering, or hiding in otherwise normal animals. Vomiting, diarrhea, abdominal distress, salivation, blindness, unusual thirst or appetite, and flank biting are other signs.

There is an obvious lack of awareness, though usually not lack of consciousness. Abnormal behaviors may last minutes or hours and can be followed by a generalized seizure. Complex partial seizures are usually associated with secondary epilepsy.

Cluster seizures

Multiple seizures within a short period of time with only brief periods of consciousness in between. May be confused with status epilepticus.

Status epilepticus

Status can occur as one continuous seizure lasting 30 minutes or more, or a series of multiple seizures in a short time with no periods of normal consciousness. It can be difficult to tell status epilepticus from frequent cluster seizures, but both are considered life-threatening emergencies.

Most status patients usually suffer from generalized tonic-clonic seizures. Though status epilepticus can occur with either primary or secondary epilepsy, it may also suddenly arise in dogs with no previous history of seizures (traumatic brain injury, toxins, or disease).

What Is a “Seizure Threshold”?

Dr. Alexander de Lahunta of Cornell University and others suggest that each animal inherits a “genetically determined predisposition to seizures,” and that seizures occur when this threshold is exceeded. In other words, a physical condition that may cause seizures in a low-threshold animal may not cause seizures in a “normal” animal.

The seizure threshold is apparently exceptionally low in animals that suffer from idiopathic (primary) epilepsy. An animal’s threshold can also be altered by other means. Certain types of tranquilizers (e.g., acepromazine) may induce seizures in animal with a low threshold. The medical condition of alkalosis is reported to decrease the threshold.

Karen R. Dyer, DVM, Ph.D, and Linda G. Shell, DVM, Dilp. ACVIM, note that there is “convincing experimental evidence” that repetitive seizures can “irreversibly lower the seizure threshold” in a process called kindling. William Fenner, DVM and Julie Haas, DVM, describe kindling as a mechanism in which epileptic neurons in the brain “recruit” normal neurons into the original seizure focus, enlarging the area of the brain that can produce seizures. Linda Shell, DVM describes kindling as the “increased excitability of neurons,” and notes that normal neurons, sufficiently stimulated, become increasingly able to cause seizures independent of outside stimulation.

The mirror focus phenomenon also deserves mention. Each hemisphere of the brain is a “mirror image” of the other. A seizure focus on one side of the brain will show itself as abnormal wave forms on EEG recordings. Within a period of weeks, the “normal” side of the brain will start to show similar EEG abnormalities. In time, the mirror focus becomes capable of causing seizure activity on its own. Thus, repetitive, uncontrolled seizures also lower the seizure threshold in any given animal. That is why early intervention is so important in the control of seizures.

Stages of a Seizure

There are 4 basic stages to a seizure:

  1. The prodome may precede the actual seizure by hours or days. It is characterized by a change in mood or behavior. Human epileptics experience mood changes, headaches, insomnia, or feelings about the impending seizure. It is not known whether animals experience a prodome except for any behavioral changes observed by their humans.
  2. The aura signals the start of the seizure. Signs include restlessness, nervousness, whining, trembling, salivation, affection, wandering, hiding, hysterical running, and apprehension.
  3. The ictus is the actual seizure, characterized by sudden increase in tone of all muscle groups. The ictus is either tonic or tonic-clonic, generally lasting 1–3 minutes.
  4. The postictus may be the only sign of epilepsy you see, particularly because many seizures occur at night or early in the morning. For minutes to days after the seizure, the dog may be confused, disoriented, restless, or unresponsive, or may wander or suffer from transient blindness. At this stage the animal is conscious but not functional.

What can you do when your dog seizures? Note the time to determine how long the seizure lasts. Keep the dog as quiet as possible. Loud or sharp noises may prolong the seizure or make it worse. Other dogs should be removed from the area, as they may disturb or attack the seizuring dog.

Should you attempt to comfort the animal? Opinions on this vary. My own dog is comforted by my presence and looks for me as he returns to consciousness. I make a point of calmly maintaining physical and voice contact with him throughout the seizure and during recovery.

Here’s a veterinarian with more on what causes seizures in dogs:

Diagnosing Epilepsy

What to do if you think your dog has had a seizure? Veterinarians have a number of diagnostic tools at their disposal.

For dogs who have had only one isolated seizure, a complete physical and neurological examination is in order. You will be advised to watch for further seizures if no abnormalities are found. Medical treatment will not be instituted until future activity can be noted.

For every patient having more than one seizure, a minimum database should be developed. The database contains the patient’s profile, history, results of complete physical and neurological examinations, and basic tests. The profile consists of the dog’s breed, age, and sex. Pertinent history includes vaccinations, potential exposure to toxins, diet, any illnesses or injuries, behavioral changes, and whether seizures occurred in any animal related to the dog.

You’ll also be asked to give a complete description of the seizures: frequency, duration, and severity, as well as any behavioral abnormalities associated with them. An accurate description is important because there are other conditions with symptoms that mimic seizures, such as cardiac and/or pulmonary disease, narcolepsy, cataplexy, myasthenia gravis, and metabolic disturbances.

When the results of the examinations and tests have been analyzed, one of three conclusions will be drawn: a definitive diagnosis, a potential cause of seizures requiring further tests to confirm, or no suggestion of a cause.

When further tests are required, a complete datebase should be done. This may include computed tomography or magnetic resonance imaging; CSF analysis (cell count, protein levels, pressure), skull radiographs, and an EEG.

Treatment

Medical treatment is generally advised for animals who have one or more seizures per month. Animals who have cluster seizures or go into status epilepticus may be treated even though the rate of incidence is greater than once per month.

Successful drug therapy depends upon your dedication to delivering the drug exactly as prescribed, with no changes in the dose or type of medication without veterinary consultation. Haphazard drug administration or abrupt changes in medication is worse than no treatment and may cause status epilepticus.

William Thomas, DVM, MS, feels it important to remember that the goal of treatment is to decrease the frequency and severity of seizures and avoid unacceptable side effects. It may not be possible to stop the seizures altogether.

A number of drugs and some alternative therapies may be used to control epilepsy. Phenobarbital and primidone are the most widely used anticonvulsant drugs, but others have their place in treatment as well.

  • Phenobarbital is one of the most commonly prescribed drugs.
  • Primidone’s side effects include sedation when treatment is initiated, and eating or drinking more than usual. High concentrations of liver enzymes have been reported with prolonged treatment at high dosages.
  • Diazepam (Valium) is used for treatment of status epilepticus.

Monitoring Drug Treatment

In order for any drug therapy to be effective, the amount of drug found in the body (serum concentration) must be consistently monitored. No 2 animals may react to the same dose in the same way.

If your dog is on medication, work with your veterinarian in observing your dog and testing the serum levels to ensure your dog is receiving the appropriate amount of drug to achieve control and avoid side effects.

Why Treatment Fails

There are many reasons medical treatments can fail:

  • The biggest reason is the human’s lack of proper administration of the prescribed drug.
  • The progression of an underlying disease (such as a brain tumor) may resist treatment.
  • Also, gastrointestinal disorders can affect drug absorption, and tranquilizers may stimulate seizures.
  • Drug interactions can occur and adversely affect the level of anticonvulsant drug in the dog’s system.
  • And it just might be that a particular drug may not work for that animal.

Parting Considerations

If your dog is experiencing either mild or severe seizures, there is help for both of you. Work with a veterinary professional with whom you feel a good rapport, and educate yourself on seizures and their treatment.

Follow the vet’s instructions, never change medication or dosages without a consultation, be observant, monitor serum levels as recommended, have patience, and be willing to try another form of treatment if that seems indicated.

Above all, if your breed club sponsors a health registry or research project on seizures or epilepsy in your breed, participate fully in it. New research on epilepsy is being done each year in an effort to determine how it’s inherited and, ultimately, to design a test that will allow breeders to select against this health defect.

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